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KMID : 0617319910010010097
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Journal of Pharmacetical Sceiences Ewha Womans University
1991 Volume.1 No. 1 p.97 ~ p.107
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Effect of Carbon Monoxide on the Monoamine Neurotransmitter and Synthetic Enzyme in Rat Brains
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Abstract
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We studied the effect of carbon monoxide(CO)-induced bypoxia on monoamine neurotransmitter and their synthetic enzyme in rat brain. When the rats were acute or chronic intoxicated at CO 5000 ppm for 30 minutes or 2000ppm for 1 week each 3hours, dopamine content increased significantly with decreasing of its turnover on striatum and norepinephrine content was diminished in hypothalamus. 5-hydroxytryptamine content was increased significantly and its turnover was decreased both in striatum and hypothalamus. Tryosine hydroxylase activity was reduced in striatum. These results suggest that inhibition of TH activity in CO-induced hypoxia is owing to lack of oxygen supply threfore NE content is decreased. We suggest that increasing of dopamine and 5-hydroxytryptamine are due to reduction of its turnover.
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